If you’ve been recently diagnosed with early stage, estrogen receptor-positive (ER+), HER2-negative (HER2-) breast cancer, the Oncotype DX Breast Recurrence Score test can help you and your doctor understand what treatment options are right for you—including whether you’re likely to benefit from chemotherapy.1,2
The Breast Recurrence Score test looks at several cancer-related genes in your tumor tissue. Because every woman’s tumor is unique, understanding the biology of your specific tumor will help you and your doctor make more confident decisions about your care.
How the test works
The Breast Recurrence Score test is a genomic test—it looks at the activity of tumor genes. Specifically, the test measures the activity of a group of cancer-related genes in your tumor tissue. The activity of these genes can provide information about how your tumor might behave in the future, including how likely it is to grow and spread or whether it is likely to respond to chemotherapy (in addition to hormonal therapy).
After the test, you’ll get a score between 0-100. A low score means the cancer has a lower chance of returning and you have a lower chance of benefiting from chemotherapy. A high score means the cancer has a higher chance of returning and you have a higher chance of benefiting from chemotherapy. Learn more about the test results.
To date, the Breast Recurrence Score test has been ordered in over 900,000 patients.3 Many women who received high Recurrence Score results were able to choose chemotherapy as a potentially life-saving treatment. The majority of women with low Recurrence Score results were able to effectively pursue hormonal therapy alone and avoid the unnecessary side effects of chemotherapy.4-11
Getting the test: No additional procedures are necessary
Getting the test is easy. Tumor tissue for the test can be taken from a procedure such as a biopsy or surgery (lumpectomy). You will NOT need any additional surgery or procedure to get the Breast Recurrence Score test.
Here’s how the test works:
STEP 1 of 6
You have surgery to remove your tumor.
STEP 2 of 6
Your doctor orders the Breast Recurrence Score test.
STEP 3 of 6
The hospital sends a sample of your tumor tissue to the Exact Sciences laboratory.
STEP 4 of 6
The Exact Sciences laboratory examines the genes in your tumor.
STEP 5 of 6
Your results are available to you doctor approximately two weeks after Exact Sciences receives your tissue.
STEP 6 of 6
You and your doctor review the results and make decisions about your treatment.
Reasons to get the Breast Recurrence Score test
There are several compelling reasons to get the test:
- It provides insight into your tumor biology that is not available from traditional measures. Without the Breast Recurrence Score test, doctors can only estimate how likely a patient’s cancer is to return by looking at factors such as age, tumor size, tumor grade, and lymph node status. The Breast Recurrence Score test provides individualized information about your tumor that’s not available from these clinical and pathologic features.
- It’s the only test proven to predict chemotherapy benefit. Several studies have consistently proven that only the Breast Recurrence Score test can predict whether you will benefit from chemotherapy.1,2 Therefore, the Breast Recurrence Score test can help you and your physician tailor a treatment plan specifically for you.
- It’s included in all major breast cancer treatment guidelines. Organizations include the National Comprehensive Cancer Network (NCCN®), American Society of Clinical Oncology (ASCO®), the St. Gallen Consensus panel, the National Institute for Health Care Excellence (NICE), and the European Society for Medical Oncology (ESMO).12-16
Get more information
- (“Have you been newly diagnosed with early-stage invasive breast cancer?”) Breast Recurrence Score Patient Brochure
- (“Patient Guide to Early-stage Invasive Breast Cancer Surgery and Treatment”) Breast Recurrence Score Patient/Surgeon Workbook