Frequently Asked Questions

What is a genomic test?

The Oncotype DX Colon Recurrence Score test is a genomic test. That means it looks at the genes of your tumor. Specifically, the Colon Recurrence Score test looks at the activity of genes that provide real insights into cancer tumor biology. Read more about the Colon Recurrence Score test.

When should the Oncotype DX test be used for people who have colon cancer?

The Oncotype DX Colon Recurrence Score test is for patients who:

  • Have been diagnosed with stage II or stage III A/B colon cancer.
  • Have had surgery to remove the tumor.
  • Have not yet started chemotherapy or other treatment.

The test is performed after the surgery to remove your tumor, but before you start treatment—since it’s meant to help guide treatment decisions. Learn more about how the Colon Recurrence Score works.

What kind of information does the test provide, and how can it help me?

Using a score between 0-100, the Oncotype DX Colon Recurrence Score test shows the likelihood of colon cancer returning.

For stage II patients
The Recurrence Score result shows the likelihood of colon cancer returning within three years of the initial diagnosis, if treated with surgery alone.

For stage III A/B patients
The Recurrence Score result shows the likelihood of colon cancer returning within five years of the initial diagnosis, if treated with 5-FU/LV chemotherapy, along with the absolute benefit of adding oxaliplatin to your chemotherapy regimen.

The results of your Colon Recurrence Score test can help you and your doctor decide on the most appropriate treatment for you, based on the biology of your individual cancer.

Will my insurance cover the Oncotype DX test?

The Oncotype DX Colon Recurrence Score test is covered by Medicare, and private insurance coverage varies. Exact Sciences’s patient assistance program helps eligible patients navigate insurance and other payment options for Oncotype DX tests. Learn more about insurance coverage and financial assistance.

How do I get tested?

The Oncotype DX Colon Recurrence Score test is performed on tissue removed during your initial surgery (resection), so no additional procedures or samples are needed. Your doctor should order the test after your surgery and before you start any chemotherapy. Find out if you’re eligible for the test.

How long does it take to get the test results?

Results are usually available within two weeks from the date laboratory processing begins. MMR testing requires an additional 1-2 additional days. The results get sent to your doctor so he or she can discuss them with you and answer your questions. The pathologist who submitted the sample also receives a copy of your results.

Why do I need to know my MMR status?

Studies have shown that stage II colon cancer patients who have MMR-deficient (MMR-D) tumors have a lower risk of their cancer returning compared to patients who have MMR-proficient (MMR-P) tumors.1-3 Knowing your MMR (mismatch repair) status gives you and your doctor more information to consider as you make decisions about your treatment.

Billing FAQs

What is the GAP?

To ensure patients can focus on their health, Exact Sciences created the Genomic Access Program (GAP), which helps eligible patients determine payment options for our tests. We work with providers, patients, and insurance companies to investigate coverage and complete any prior authorization requirements, where applicable.

How much will this test cost me/how much does the test cost?

Out-of-pocket (OOP) costs for the test, if any, are determined by the insurance company. You may have financial responsibility for a co-pay, co-insurance, deductible, or non-covered charges as determined by your insurance. We strongly encourage patients to contact their insurer when they have questions about their plan design and benefits.

How will I know if my insurance covers testing?

Coverage depends upon various factors, such as your insurance’s medical necessity criteria and benefit plan design. Your out-of-pocket costs for the test, if any, are determined by your insurance company. 

What if I don’t have any health insurance coverage?

If you don’t have insurance, our Customer Service team will help you determine your eligibility for financial assistance and explore the best options available to you.

Do I qualify for any financial assistance?

Exact Sciences offers financial assistance for eligible patients based on the Federal poverty guidelines. If eligible, both insured and uninsured patients will have no out-of-pocket costs. Click here to see if you could be eligible for testing at no cost. To complete our full financial assistance application, please see/download The FINANCIAL ASSISTANCE (FA) DISCLOSURE FORM AND APPLICATION for more information. Disclaimer: Exact Sciences may modify or terminate its Genomic Access Program (GAP) and/or financial assistance options at any time.

Do you offer payment plans?

Yes, we offer flexible payment plan options. You can sign up for a payment plan using our patient portal or by speaking to Customer Service. We also offer automatic monthly bill payment options as well.

Does Medicare cover testing?

Testing is covered by Medicare Fee for Service (FFS) for patients meeting coverage criteria. Patients who meet clinical criteria for coverage usually have zero financial responsibility. For patients who do not meet Medicare criteria, an Advanced Beneficiary Notice (ABN) is required before receiving services considered not medically necessary. In these instances, you will be responsible for the test cost should you still choose to proceed.

What do I do if my health insurance sent me a check directly?

In the event your insurance company sent you a payment to cover the testing performed by Exact Sciences, please forward the payment to us using the instructions below. If you have already cashed the check from your insurance, you can mail a personal check to us or make an electronic payment via our patient portal.

  1. Endorse the back of the check by signing your name and writing “Pay to the Order of Exact Sciences”.

  2. Mail check to:
    Exact Sciences
    PO Box 742415
    Los Angeles, CA 90074-2415

  3. Include any paperwork you received from your insurance company with your payment. Otherwise, ensure your full name, date of birth, and mailing address are enclosed so we can apply the payment to your account.
How can I pay my bill/balance?

Our convenient patient portal is an easy way to check your account balance, set up payment plans, or make recurring payments automatically. Visit My Lab Bill for more information.

How do I appeal a denial decision from my insurance?

With your consent, Exact Sciences can pursue appeals on your behalf if appeal options are available. The appeal process can take several months.

How do I provide my insurance information or updated insurance information?

Please contact Customer Service to provide this information.

I received an explanation of benefits (EOB) from my insurance, is this a bill?

You may receive multiple EOBs from your insurance. You will only receive a bill from Exact Sciences if payment is required after the claim is fully processed. Contact Customer Service with any questions.

1. Ribic et al. N Engl J Med. 2003.
2. Sargent et al. J Clin Oncol. 2010.
3. Klingbiel et al. Ann Oncol. 2015.

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