An estimated 50,000 mCRPC patients each year could benefit from knowing their nuclear AR-V7 status
It's estimated that about 50,000 metastatic castration-resistant prostate cancer (mCRPC) patients each year could benefit from knowing their nuclear AR-V7 status prior to selecting treatment. Advanced prostate cancer patients who become resistant to next generation-hormonal therapies or androgen receptor (AR)-targeted therapies, such as apalutamide, abiraterone, or enzalutamide, may often respond to taxane chemotherapy.1,2,3 The Oncotype DX AR-V7 Nucleus Detect test can help you confidently choose the therapy that will help offer your patients the opportunity for longer overall survival.
The AR-V7 Nucleus Detect assay is ideal for patients who:
- Have confirmed mCRPC
- Have received and failed AR-targeted therapy
- Are considering additional AR-targeted therapies
When to order the AR-V7 Nucleus Detect test
Ordering the AR-V7 Nucleus Detect test is appropriate for mCRPC patients who have failed an AR-targeted therapy like apulatamide (Erleada®), abiraterone (Zytiga®), and enzalutamide (Xtandi®).
Why order the test after failure on AR-targeted therapy
Although AR-targeted therapies are a breakthrough in mCRPC treatment, it’s important to remember that some patients never respond to AR-targeted therapies and many patients who initially respond to AR-targeted therapies develop acquired resistance to them over time.4
The percentage of patients who are nuclear AR-V7+ (an absolute indicator that a patient will not respond to AR-targeted therapies) increases with each exposure to a line of therapy, including AR targeted therapies5:
- Roughly 1 in 5 patients (18%) are nuclear AR-V7+ after receiving one round of therapy
- Roughly 1 in 3 patients (31%) are nuclear AR-V7+ after receiving two rounds of therapy.
The percentage of mCRPC patients with the AR splice variant -7 (AR-V7+) increased with continued treatment exposure5
Cross-sectional cohort study. Blood samples were collected from 161 patients with mCRPC and tested for the presence of AR-V7.