How Does It Compare to Other Tests?

The only assay designed for critical treatment decisions in low-, intermediate-, and high-risk prostate cancer patients. See how the Oncotype DX GPS test compares to other genomic tests:

Comparison of prostate biopsy genomic tests

  Oncotype DX GPS assay Prolaris® Test Decipher® Prostate Biopsy Test
Genes selected based on their performance in prostate cancer in the biopsy setting1-4 checkmark
Extensive clinical validation across large cohorts of GS 3+3 and 3+4 patients who are eligible for active surveillance1,4-20 checkmark
Optimized and analytically validated for small prostate biopsy tissue samples2,10,19 checkmark
5 ng of RNA
200 ng of RNA 25-100 ng of RNA

Validated endpoints in a biopsy setting:

Oncotype DX GPS assay
Prolaris® Test
Decipher® Prostate Biopsy Test
  • Metastasis after RP13
  • PCM after RP13
  • AP (Gleason grade ≥ 4+3 and/or pT3+)13*
  • BCR7,13
  • Metastasis after RP20
  • PCM after conservative management (watchful waiting)15,16
  • BCR20
  • Metastasis after RP3
  • PCM after RP3
  • AP (Gleason ≥ 4+3 and pT3b+ only)17*
  • RP = radical prostatectomy; BCR = biochemical recurrence; PCM = prostate cancer mortality
    *Prospective validation data for this clinical endpoint.21


    * Adverse Pathology is defined as high-grade and/or non-organ-confined disease.

    1. Klein et al. Eur Urol. 2014.
    2. Cuzick et al. Lancet Oncol. 2011.
    3. Nguyen et al. Eur Urol. 2017.
    4. Erho et al. PLoS ONE. 2013.
    5. Badani et al. Urol Pract. 2015.
    6. Bonham et al. USCAP. 2016.
    7. Cullen et al. Eur Urol. 2015.
    8. Dall’Era et al. Urol Pract. 2015.
    9. Eggener et al. Urology. 2019.
    10. Knezevic et al. BMC Genomics. 2013.
    11. Lynch et al. Am J Manag Care. 2018.
    12. Salmasi et al. J Urol. 2018.
    13. Van Den Eeden et al. Eur Urol. 2017.
    14. Eure et al. Urology. 2017.
    15. Cuzick et al. Br J Cancer. 2015.
    16. Cuzick et al. Br J Cancer. 2012.
    17. Kim et al. Prostate Cancer Prostatic Dis. 2018.
    18. Albala et al. Rev Urol. 2016.
    19. Klein et al. Urol. 2016.
    20. Bishoff et al. J Urol. 2014.
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