Why Get the Oncotype DX Genomic Prostate Score Test?

If you have been diagnosed with low-risk prostate cancer, discussing management options with your doctor is typically the next step. It’s important that you give yourself time to understand what your diagnosis means, and what option will be best for your specific cancer at this specific time.

The Oncotype DX test gives you and your doctor more information for treatment conversations and decisions.

Oncotype DX is a genomic test, meaning that it measures the expression of certain genes in prostate cancer cells. The results of Oncotype DX are reported as a Genomic Prostate Score (GPS), which can help you and your doctor more confidently make decisions about a management plan that’s best for you.

Informing Your Treatment Decision

How the test can help you

The Oncotype DX GPS test is called a genomic test. It measures the activity (also referred to as expression) of 17 select genes responsible for the growth and survival of tumor cells. The results of the test are reported as a Genomic Prostate Score, GPS.

This information allows the Oncotype DX GPS test to clarify how the tumor may act and whether it is likely to be aggressive (adverse pathology).

The test also predicts whether you are likely to die from your cancer or have it spread to other parts of your body (metastasis) within 10 years of surgery.

In addition to your clinical factors, the Oncotype DX GPS test will provide information for you and your doctor to discuss next steps.

Why your tumor’s gene activity matters

Not all prostate cancers are the same—some are aggressive and require treatment with surgery or radiation therapy. However, many are lower risk and can be managed with regular doctor visits and monitoring called active surveillance—delaying or completely avoiding treatments like surgery or radiation.

It’s important for you to understand your personal risk before deciding on a management plan—with this information in hand you can make a decision that is best suited to helping you live as long and healthy a life as possible. Oncotype DX GPS will help you and your health care team understand your individualized risk to better inform decisions about what happens next—active surveillance or treatment.

Choosing active surveillance

If you have been diagnosed with clinically low-risk prostate cancer, you may be able to delay or even avoid aggressive treatments like surgery or radiation. Instead, you may be able to safely monitor your prostate cancer through a program of regular check-ups and tests known as active surveillance.

Active surveillance is a treatment plan for patients whose tumor is not likely to be aggressive. It involves regular check-ups and ongoing testing, which may include1:

  • PSA (prostate-specific antigen) testing
  • Regular exams (DRE, digital rectal exams)
  • Repeat biopsy as recommended by your doctor

When to have the test

If you have been recently diagnosed with low-risk prostate cancer or have yet to decide on a management option, your biopsy tissue may be used to provide additional information about the aggressiveness of your tumor, which may help you choose the right treatment plan. See if you could be eligible.

What’s needed to perform the test

The Oncotype DX GPS test uses a tissue sample from a biopsy performed within the last three years. So, if you’ve had a recent biopsy, no additional procedure is needed.

The test can predict the aggressiveness and biology of the prostate cancer without additional tests or having to remove the tumor by analyzing a very small sample of the tumor tissue.

Oncotype DX GPS is the only genomic test that was designed specifically for use in men with clinically low risk cancer who are deciding between active surveillance or treatment

Discuss using the Oncotype DX GPS with your doctor to make the decision together about whether it would provide more confidence to guide important decisions about treatment. It’s essential that you have all the facts and consider your options before choosing a course of action to treat prostate cancer.


Your Oncotype DX Genomic Prostate Score Can Help You Navigate Through Your Treatment Options

Get more info on how the Oncotype DX GPS can help inform your treatment options for prostate cancer.



1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) (Version1.2017). © National Comprehensive Cancer Network, Inc. 2017. All rights reserved. Accessed January 10, 2017. To view the most recent and complete version of the guidelines, go to www.nccn.org. NATIONAL COMPREHENSIVE CANCER NETWORK®, NCCN®, NCCN GUIDELINES®, and all other NCCN Content are trademarks owned by the National Comprehensive Cancer Network, Inc.

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